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NASA Spaceline Current Awareness List #1,161 8 August 2025 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #1,161 8 August 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Balasubrahmaniam N, Nastasi N, Hegarty B, Horack JM, Meyer ME, Haines SR, Dannemiller KC.Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS).Sci Rep. 2025 Aug 4;15:28366.PI: K.C. DannemillerNote: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.9

Funding: The authors would like to thank Dr. Mark Ott, staff at the NASA Microbiology Laboratory, and staff at the Toxicology and Environmental Chemistry (TEC) for help in obtaining dust from the International Space Station. The authors would like to thank Dr. Ashleigh Bope for assistance with writing the initial draft and implementing the bioinformatics pipeline. The authors would also like to acknowledge National Aeronautics and Space Administration (NASA) grant 80NSSC19K0429 and National Science Foundation (NSF) grant 1942501 to support the work.”

Khan F, Ansingkar K, Dongre R, Mehdi Z, Dhanda AK, Powell K, Syed T, Razmi SE, Somawardana I, Vrabec JT, Hilmers D, Ahmed OG, Takashima M.Congestion and sinonasal illness in outer space: A study on the International Space Station.Laryngoscope Investig Otolaryngol. 2025 Aug;10(4):e70229.Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 1.7

Funding: “The inflight ENT data was provided by Wafa Taiym of the Lifetime Surveillance of Astronaut Health (LSAH) Program, NASA Johnson Space Center.”

Buras WR, Hilmers DC.Developing artificially intelligent agents to support Earth independent medical capabilities during human exploration-class space missions.npj Microgravity. 2025 Aug 2;11:51.Note: From the abstract: “Artificially-intelligent agents are in development to support NASA crewmembers during exploration missions where earth-based medical support is unfeasible. We describe the need for such agents, provide a functional overview, and present a concept of operations demonstrating how they could support crew health. We list desirable characteristics to support crew medical officers. We suggest that this technology can also be applied in remote terrestrial environments where expert consultation is inaccessible.” This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: “We would like to thank NASA and TRISH for their past and ongoing research support of these technologies. This work was supported by NASA SBIR funding under grant numbers NNX16CC522P, NNX17CC12C, 80NSSC120C0541, 80NSSC21C0578, 80NSSC23PB612.”

Mokhtari M, Reinsch SS, Barcenilla BB, Ziyaei K, Barker RJ.Space-driven ROS in cells: A hidden danger to astronaut health and food safety.npj Microgravity. 2025 Aug 4;11(1):52. Review.Note: This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: S.S. Reinsch and R.J. Barker are affiliated with NASA Ames Research Center.

Opdensteinen P, Affonso de Oliveira JF, Jung S, Steinmetz NF.Toward translation of cowpea mosaic virus intratumoral immunotherapy with a scalable production process.Plant Biotechnology Journal. 2025 Jul 29. Online ahead of print.PI: P. OpdensteinenNote: This article may be obtained online without charge.

Journal Impact Factor: 10.5

Funding: “This work was supported by the Translational Research Institute for Space Health through Cooperative Agreement NNX16AO69A and National Institutes of Health (R01-CA274640).”

Poignant F, Huff JL, Kunkel SR, Plante I, Slaba TC.Effect of fluorescence in situ hybridization detection threshold on chromosome aberration counting: A simulation study.Life Sci Space Res. 2025 Aug 1;46:154-68.Note: From the abstract: “In this work, we introduced a new chromosome aberration classification approach in the simulation code RITCARD (Radiation induced tracks, chromosome aberrations, repair, and damage), that accounts for FISH detection threshold and the use of different chromosome painting probes. We also modified our 3D nuclear architecture model using Hi-C data to generate the DNA distribution within cell nuclei with the tool G-NOME. This new approach allowed the discrimination of true simple and complex exchanges from apparently simple exchanges (complex exchanges detected as simple), as well as undetected exchanges.”

Journal Impact Factor: 2.8

Funding: “This work was supported by the NASA Langley Research Center contract 80LARC22R0003 (F.P.); the Human Research Program under the Space Operations Mission Directorate at NASA (J.H., T.S.); and the NASA Human Health and Performance contract NNJ15HK11B (I.P.).”

Drew KL, Fedorov VB, Duddleston KN, Tøien Ø.Harnessing hibernation: Unlocking nature’s secrets for advances in healthy aging, critical care, and space exploration.Ann N Y Acad Sci. 2025 Aug 4. Online ahead of print.Note: This article may be obtained online without charge.

Journal Impact Factor: 4.8

Funding: “NASA EPSCoR Program; P20GM103395/NH/NIH HHS/United States; P20GM130443/NH/NIH HHS/United States.”

Sparks JA, Sun L, Chin S, Ramanjulu N, Wen J, Gilroy S, Blancaflor EB, Khan BR.Mutations adjacent to the nucleotide-binding cleft of Arabidopsis thaliana ACTIN7 confer resistance to the actin-disrupting compound latrunculin B.J Exp Bot. 2025 Aug 1. Online ahead of print.PI: S. Gilroy, E.B. BlancaflorJournal Impact Factor: 5.7

Funding: “This work was supported by the National Aeronautics and Space Administration (NASA) Biological and Physical Sciences Division grants 80NSSC19K0129 to EBB and 80NSSC18K1462 to SG, and start-up funds from the Biology Department, University of Scranton to BRK.”

Zhou D, López-Valiente RE, Mattar SG, Guan D.Noncanonical clock regulators control stress responses in digestive diseases.Trends Endocrin Met. Aug 1. Online ahead of print.Journal Impact Factor: 12.6

Funding: “This work was supported by CPRIT Scholar in Cancer Research (RR210029), V Foundation (V2022-026), and National Institutes of Health R37CA296577, DK056338, P30-CA125123, TRISH NNX16AO69A and H-NORC to D.G.”

Davila AF, Hoehler T, Parenteau N, Neveu M, Shkolyar S, Des Marais DJ, Cady SL, Rios AC, Bebout L, Lau G, Jahnke L, Perl S, Eigenbrode JL, Pohorille A, Quinn R.Life detection knowledge base: Taxonomy of potential biosignatures.Astrobiology. 2025 Jul 17;25(7):464-73.Note: This article may be obtained online without charge.

Journal Impact Factor: 4.8

Funding: NASA Task Book project “Center for Life Detection Research and Service (CLD-RS) — Computational Systems Biology at the Ecosystem Scale” funding.

Nanda V, Siess J, Jagilinki BP, Hazen RM, Kamerlin SCL, Koder R, Noy D, Silberg J, Tezcan FA, Ulijn R, Yee N, Falkowski P.On the emergence of metabolism: The evolution of proteins that powered life.Philos Trans R Soc Lond B Biol Sci. 2025 Aug 7;380(1931):20240090. Review.Note: This article may be obtained online without charge.

Journal Impact Factor: 4.7

Funding: “We received funding from NASA Astrobiology Institute (80NSSC18M0093).”

Astrobiology, space biology, space life science, space medicine, Microgravity, ISS,

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