NASA Spaceline Current Awareness List #1,133 24 January 2025 (Space Life Science Research Results)

editorAstrobiology3 weeks ago50 Views

NASA Spaceline Current Awareness List #1,133 24 January 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

  • Richards JT, Mortenson TE, Spern CJ, Mousseau TA, Gooden JL, Spencer LE, Khodadad CL, Fischer JA, Meyers AD, Papenfuhs CK, Buell JG, Levine HG, Dimapilis DI, Zhang Y.Simulated deep space exposure on seeds utilizing the MISSE flight facility.npj Microgravity. 2025 Jan 17;11:3.Note: ISS results. This article may be obtained online without charge.

    Journal Impact Factor: 5.1

    Funding: “This project was funded by both the Flight Opportunity Program and the NASA Biological and Physical Sciences Division as a pathfinder technology demonstration for future Space Biology investigations using the MISSE platform. TAM’s participation was in part supported by a SURA LASSO/NASA visiting scientist award and funding from the Samuel Freeman Charitable Trust. We also thank the KSC’s EDL for conducting the thermal test, and the Cryogenics Test Laboratory (CTL), especially James E. Fesmire and Adam M. Swanger, for recommendations on insulation material selections. We thank especially Matthew W. Romeyn (KSC) for his recommendation on seed selection, Trent M. Smith (KSC) for his technical advice, and Bill Wells (the Bionetics Corporation) and Mark Shumbera (Aegis Aerospace Inc.) for their support. We give special thanks to astronauts (JAXA astronaut Soichi Noguchi, and NASA astronauts Kayla Barron and Mark Vande Hei), the Aegis team, and the whole ISS team for supporting and operating the MISSE-14 payload.”

  • Clement K, Nemec-Bakk AS, Jun SR, Sridharan V, Patel CM, Williams DK, Newhauser WD, Willey JS, Williams J, Boerma M, Chancellor JC, Koturbash I.Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: Sex-specific epigenetic reprogramming.Radiat Environ Biophys. 2025 Jan 22.PI: J.C. ChancellorNote: : Hindlimb unloading was used to simulate exposure to microgravity.

    Journal Impact Factor: 1.5

    Funding: “This work was supported by NASA, grant # 80JSC019N001-HHCBPSR; Clinical and Translational Science Awards UL1TR000039 and KL2TR000063; NIGMS, grant P20 GM109005, and the Arkansas Biosciences Institute.”

  • Josan PK, Dutta P, Abbott R, Martin AV, Dunbar BJ, Wong RKW, Selva D, Diaz-Artiles A.Virtual assistant for spacecraft anomaly resolution: Effects on human performance metrics.J Aerosp Inform Syst. 2025 Jan 3. Online ahead of print.PI: D. SelvaNote: From the abstract: “Virtual assistants (VAs) are known to improve performance, reduce mental workload (MWL), and improve situational awareness (SA) in complex cognitive tasks. However, there is a lack of studies focusing on anomaly resolution tasks in time- and safety-critical environments such as long-duration exploration missions. This paper aims to investigate the effects of using a VA, namely Daphne-AT, on crew performance, SA, and MWL in the context of spacecraft anomaly treatment.”

    Journal Impact Factor: 1.3

    Funding: “This work was funded by the NASA Human Research Program grant number 80NSSC19K0656, as part of Human Capabilities Assessment for Autonomous Missions Virtual NASA Specialized Center of Research effort. The authors would like to acknowledge Human Exploration Research Analog (HERA) management team for their continuous support in providing access to the Habitat Simulation System, related technical support, and delivery of associated anomaly resolution procedures.”

  • Casaletto JA, Scott RT, Myrick M, Mackintosh G, Chok H, Saravia-Butler A, Hoarfrost A, Galazka JM, Sanders LM, Costes SV.Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble.Sci Rep. 2025 Jan 18;15(1):2363.Note: From the abstract: “In this work, we use a machine learning ensemble of causal inference methods called the Causal Research and Inference Search Platform (CRISP) which was developed to predict causal features of a binary response variable from high-dimensional input. We used CRISP to identify genes robustly correlated with a lipid density phenotype using transcriptomic and histological data from the NASA Open Science Data Repository (OSDR).” This article may be obtained online without charge.

    Journal Impact Factor: Not available for this journal

    Funding: “This research was supported by the NASA Human Research Program (HRP), Science Mission Directorate, and Biological and Physical Sciences (BPS) Division. We thank the HRP Radiation Element Translational Radiation Research and Countermeasures team and the GeneLab team for collaboration. Resources supporting this work were provided by the NASA High-End Computing (HEC) Program through the NASA Center for Climate Simulation (NCCS) at Goddard Space Flight Center. We also wish to thank Charlotte Nelson from Mate Bioservices, Inc. for providing us the results from the SPOKE tool.”

  • Shepanek MA.Behavioral health for long-duration space missions.In: Krittanawong C, ed. Precision Medicine for Long and Safe Permanence of Humans in Space: Academic Press. 2025. p. 57-9.Funding: M.A. Shepanek is affiliated with NASA Headquarters.
  • Possnig C, Marume K, Babu G, Janssen S, Hearon CM, Jr., Dias KA, Sarma S, Lawley JS, Levine BD.Regional changes in cerebral blood flow between the upright and supine posture and over 3 days of bedrest.Exp Physiol. 2025 Jan 22. Online ahead of print.PIs: J.S. Lawley/B.D. Levine/NSBRINote: This article may be obtained online without charge.

    Journal Impact Factor: 2.6

    Funding: “This work was supported by the National Space Biomedical Research Institute (NSBRI) Grant CA 00005 through the National Aeronautics and Space Administration cooperative agreement NCC 9-58-49.”

  • Siegel B, Spry JA, Seasly E, Benardini JN.Status update of NASAs assessment of the biological contamination threat of crewed Mars surface missions.Life Sci Space Res. 2025 Jan 22. Online ahead of print.Journal Impact Factor: 2.9

    Funding: B. Siegel, E. Seasly, and J.N. Benardini are affiliated with NASA Headquarters.

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