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NASA Spaceline Current Awareness List #1,166 12 September 2025 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #1,166 12 September 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Rithidech K, Mohallem R, Aryal UK, Peanlikhit T, Crucian B.Effects of the space environment and re-adaptation to Earth’s gravity on astronauts’ plasma proteome.Life Sci Space Res. 2025 Sep 9. Online ahead of print.PI: K. RithidechNote: ISS results.

Journal Impact Factor: 2.8

Funding: “This research was supported by the National Aeronautics and Space Administration (NASA) Grant # NNX16AH80G, awarded to Dr. Rithidech. Proteomic analysis was performed at the Purdue Proteomics Facility, Bindley Bioscience Center. The authors wish to thank the International Space Station astronauts who participated in this study. The authors thank the NASA Human Research Program, Human Health, and Countermeasures Element for the selection and support of this investigation.”

Crucian B, Diak DM, Garbino A, Gutierrez C, Bustos-Lopez S, Colorado A, Young M, Smith SM, Zwart SR, Oswald TM, Hew-Yang MY, Estep P, Marshall-Goebel K, Mehta S.Effects of hypoxia/hyperoxia exposure on immune function – Results from a spacecraft-relevant hypobaric chamber study.Front Physiol. 2025 Sep 8;16:1637834.Note: This article and an article below (Gorini Pereira et al.) in the “Other” section are part of Research Topic “Bioconvergence: A New Frontier for Understanding and Enhancing Human Adaptations to Extreme Environments” (https://www.frontiersin.org/research-topics/68632/bioconvergence-a-new-frontier-for-understanding-and-enhancing-human-adaptations-to-extreme-environments). Additional articles will be forthcoming and may be found in the link to the Research Topic. This article may be obtained online without charge.

Journal Impact Factor: 3.4

Funding: “The author(s) declare that financial support was received for the research and/or publication of this article. The overall chamber study as a Program level evaluation was funded by the NASA JSC Extravehicular Activity and Human Surface Mobility Program. This included the immunological sub-study, for all immediate analyses. Additional funding for analysis of all frozen biosamples was provided by the NASA Human Research Program, Human Health and Countermeasures Element.”

Rhoades J, Mangle K, de León P, Crisman K, Manyapu K.Study on parastronaut ingress and egress of Orion and Boeing CST-100 starliner space vehicles.Acta Astronaut. 2025 Nov;236:904-13.Note: From the abstract: “This preliminary investigation aimed to observe individuals with disabilities participating in the ingress and egress procedures of Lockheed Martin’s Orion and Boeing’s CST-100 Starliner spacecraft.”

Journal Impact Factor: 3.4

Funding: “The National Aeronautics and Space Administration funded this project. Grant Number: 22-NUP2022-0061; UNSOL_FY2022.”

Tays GD, McGregor HR, De Dios YE, Mulder E, Bloomberg JJ, Mulavara AP, Wood SJ, Seidler RD.Thirty minutes of daily artificial gravity does not mitigate head down tilt induced brain activity changes during cognitive task performance.Front Neurol. 2025 Aug 26;16:1602104.PI: R.D. SeidlerNote: This article is part of Research Topic “Impact of Vestibular Dysfunction Studies on Space Flight Health Challenges” (https://www.frontiersin.org/research-topics/53190/impact-of-vestibular-dysfunction-studies-on-space-flight-health-challenges). The Research Topic also includes articles from previous Current Awareness Lists #1,075 https://doi.org/10.3389/fneur.2023.1284029, #1,139 https://doi.org/10.3389/fneur.2025.1556553, and #1,164 https://doi.org/10.3389/fneur.2025.1628938. This article may be obtained online without charge.

Journal Impact Factor: 2.8

Funding: “This work was supported by grants from the National Aeronautics and Space Administration (NASA 80NSSC18K0783) to RS, AM, SW, and JB. During the completion of this work GT was supported by the University of Florida’s (UF) Graduate Student Funding Award and by NIH T32-NS082128.”

Pham J, Isquith J, Balaian L, Nandi SP, Engstrom C, Mack K, van der Werf I, Chang P, Stoudemire J, Ladel L, Klacking E, Ruiz A, Chilin-Fuentes D, Sneifer J, Mays D, Gamble P, Giza S, Janowitz J, Nienaber T, Mishra T, Khachatrian AA, Molina E, Snyder MP, Morris SR, Clements T, Muotri AR, Whisenant T, Alexandrov LB, Jamieson CHM.Nanobioreactor detection of space-associated hematopoietic stem and progenitor cell aging.Cell Stem Cell. 2025 Sep 4;32(9):1403-20.e8.Note: This article may be obtained online without charge.

Journal Impact Factor: 20.4

Funding: “…This work was supported by the Sanford Stem Cell Institute, the SCRM microscopy core, and the NGS Core Facility of the Salk Institute. We are grateful to our funding agencies for their vital support, including NASA (NRA NNJ13ZBG001N) to UC San Diego Sanford ISSCOR Center, NIH (R01CA296974), NCI (R01CA2 05944), NIH/NIDDK (R01DK114468-01), NIH NCI CCSG p30CA023100, NIH NCI CCSG: P30 CA01495, NIH NIA San Diego Nathan Shock Center (P30 AG068635), the Chapman Foundation and the Helmsley Charitable Trust, LLS Blood Cancer Discoveries, Koman Family Foundation, JM Foundation, and Moores Family Foundation.”

Sakharkar A, Chen R, LeRoy E, Nelson TM, Proszynski J, Kim J, Park J, Arikatla MR, Mathyk B, Mason CE.Multi-omics profiling of individuals sustaining extreme physical stressors.Life. 2025 Sep 1;15(9):1377.PI: C.E. MasonNote: This article is part of Special Issue “Space Medicine Advancements: From Human Health to Biomedical System Design” (https://www.mdpi.com/journal/life/special_issues/P9T6CD6J32) and may be obtained online without charge.

Journal Impact Factor: 3.4

Funding: “The National Institutes of Health (U54AG089334), NASA (80NSSC23K0832), The UK Cancer Grand Challenges (SAMBAI-01), and the Leukemia and Lymphoma Society (MCL7001-18, LLS 9238-16, 7029-23/22).”

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