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NASA Spaceline Current Awareness List #1,170 17 October 2025 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #1,170 17 October 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

Brunstetter TJ, Mason SS, Osborne S, Young M, Oswald T, Gibson CR, Patel N, Mader TH, Lee AG, Brown DM, Tsung A, Tarver W.Predicting spaceflight-associated neuro-ocular syndrome in International Space Station astronauts.JAMA Ophthalmol. 2025 Oct 9. Online ahead of print.Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 6.7

Funding: T.J. Brunstetter, M. Young, and W. Tarver are affiliated with NASA Johnson Space Center.

Winer DA, Du H, Kim J, Chang V, Burke M, Winer S, Costes SV, Frippiat JP, Sams C, Paul AM, Wu H, Ullrich O, Baatout S, Beheshti A, Mason CE, Choukér A, Crucian BE.Astroimmunology: The effects of spaceflight and its associated stressors on the immune system.Nat Rev Immunol. 2025 Oct 16. Review. Online ahead of print.PI: C.E. MasonNote: This article may be obtained online without charge.

Journal Impact Factor: 60.9

Funding: “…This work is also supported by ESA/BELSPO/PRODEX IMPULSE contract CO-90-11-2801-04 (S.B.). The authors also acknowledge support by the NASA Human Research Program, Human Health and Countermeasures Element, the Centre National d’Etudes Spatiales (CNES, the French Space Agency). C.E.M. thanks the WorldQuant and GI Research Foundation, NASA (NNX14AH50G, NNX17AB26G, NNH18ZTT001N-FG2, 80NSSC22K0254, 80NSSC23K0832, 80NSSC24K0728, 24-24NSCOR_2-0008, 24-24FLAG_2-0099 and 22-22SBR_2-0104), the National Institutes of Health (R01ES032638, P01CA272295 and U54AG089334) and the LLS (MCL7001-18, LLS 9238-16, 7029-23). J.K. was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF), funded by the Ministry of Education(RS-2023-00241586). …”

Karouia F, de Oliveira LC, Hameed A, Simpson A, Singh N, Rekha PD, Mason CE, Venkateswaran K.Genomic characterization of Microbacterium meiriae sp. nov., a novel bacterium isolated from the International Space Station.Sci Rep. 2025 Oct 14;15:35770.PI: K. VenkateswaranNote: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 3.9

Funding: “CEM thanks the Scientific Computing Unit (SCU) at WCM, the WorldQuant Foundation, NASA (NNX14AH50G, NNX17AB26G, NNH18ZTT001N-FG2, 80NSSC22K0254, NNX16AO69A), the National Institutes of Health (R01MH117406), and the LLS (MCL7001- 18, LLS 9238-16) © 2025 California Institute of Technology, Government sponsorship acknowledged.” “…This research was funded by a 2012 Space Biology NNH12ZTT001N grant no. 19-12829-26 under Task Order NNN13D111T award to KV, which also supported NKS and AS.”

Chauhan V, Grybas VS, Hoopfer D, Higginson C, Ainsbury EA, Azimzadeh O, Beheshti A, Blattnig S, Boerma M, Costes SV, Doty S, Adam-Guillermin C, Hamada N, Hinton P, Huff JL, Reynolds R, Wilkins RC, Wood S, Yauk CL.Adverse outcome pathways applied to space radiation research.Environ Mol Mutagen. 2025 Oct 8. Review. Online ahead of print.Note: This article may be obtained online without charge.

Journal Impact Factor: 2.3

Funding: “The work has been funded partially by the Canadian Space Agency, Health Canada Solutions Fund, and a Genomics Research and Development Initiative. Professor Ainsbury is a member of the Health Protection Research Unit in Chemical and Radiation Threats and Hazards, a partnership between UK Health Security Agency and Imperial College London, which is funded by the National Institute for Health Research (NIHR). Dr. Yauk (University of Ottawa) acknowledges that her contributions were undertaken in part thanks to funding from the Canada Research Chairs program. Drs. Huff and Blattnig are supported by the NASA Human Research Program, Space Operations Mission Directorate.”

Dixon C, Massa GD, Jones SB.Optimizing an on-demand passive fertigation system for microgravity.Gravit Space Res. 2025 Oct 9;13(1):90-102.Note: From the abstract: “Plant production in microgravity is essential for sustaining astronauts long-term space missions. However, previous containerized plant cultivations in space has yielded inconsistent results, largely due to challenges in understanding the hydraulic properties of porous media, particularly water retention characteristics (WRCs) and hydraulic potential (H) under microgravity. This study addresses the issue of over-fertigation in the root zone, a persistent challenge in past space-based systems. We propose an on-demand passive fertigation system, regulated by a check valve-controlled H and tailored to the WRCs of the porous medium.” This article may be obtained online without charge.

Journal Impact Factor: 0.2

Funding: “This study is based upon work supported by the National Aeronautics and Space Administration (NASA) under grant Nos. 80NSSC20K1411 and 80NSSC23K0755 issued through Appendix C: Development of Microgravity Food Production: Plant Watering, Volume Management and Novel Plant Research on the International Space Station (NNH18ZTT001N-PT).”

Gonzalez TJ, Boothby TC.Properties governing dry-state stability of RNA in amorphous sugar formulations.Commun Mater. 2025 Jul 1;6:129Note: This article may be obtained online without charge.

Journal Impact Factor: 9.6

Funding: NASA Grant #80NSSC20M0113.

Poignant F, Levrague V, Roccia M, Tran NH, Incerti S, Beuve M, Testa E, Plante I, Rahmanian S, Delorme R.DNA decompaction enhances the formation of radiation-induced DNA double strand breaks and chromosome aberrations.Life Sci Space Res. 2025 Oct 12. Online ahead of print.Note: This article may be obtained online without charge.

Journal Impact Factor: 2.8

Funding: “This work was supported by the NASA Langley Research Center contract 80LARC23DA003 (F.P., S.R.); the NASA Human Health and Performance contract NNJ15HK11B (I.P.), the Centre National de Recherche Scientifique (CNRS) (R.D.), the LabEx PRIMES (ANR-11-LABX-0063) within the program Investissements dâ€™Avenir operated by the French National Research Agency (ANR) (M.R., V.L.) and the ITMO Cancer AVIESAN within the framework of Cancer 2020 (V.L.).”

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