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NASA Spaceline Current Awareness List #1,179 19 December 2025 (Space Life Science Research Results)

NASA Spaceline Current Awareness List #1,179 19 December 2025 (Space Life Science Research Results)

The abstract in PubMed or at the publisher’s site is linked when available and will open in a new window.

In case you missed it: A Science Strategy for the Human Exploration of Mars is a newly published book published by the National Academies of Sciences, Engineering, and Medicine. For more information and how to access this book go to https://www.nationalacademies.org/publications/28594.

Daniel Estrella L, Sveeggen TM, de la Guardia G, Cacho J, Stauch KL, Bagher P.A systematic review of the cerebrovascular adaptations following exposure to spaceflight or ground-based analogs: Lessons from human and animal studies.npj Microgravity. 2025 Dec 12. Review. Early access article.Note: This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: HL155618/HL/NHLBI NIH HHS/United States; 80NSSC19K0392/NASA/NASA/United States

Jones-Isaac K, Yeung CK, Bain J, Lidberg K, Yang J, Wang L, MacDonald J, Bammler T, Thummel KE, Corn M, Ruiz MV, Countryman S, Koenig P, Mann HH, Himmelfarb J, Kelly EJ.Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity.npj Microgravity. 2025 Dec 11. Early access article.Note: From the article: “In the unique microgravity environment of the International Space Station National Laboratory (ISSNL), COM microcrystals are evenly dispersed in the treatment media allowing access to the proximal tubule epithelial cells lining the internal culture chamber within the kidney MPS to induce a physiological response to COM exposure. Investigating the cellular response to COM challenge in microgravity can provide insight into biochemical pathways of stone response in the kidney proximal tubule in microgravity and interrogate the mechanism of potassium citrate efficacy.” This article may be obtained online without charge.

Journal Impact Factor: 5.1

Funding: “This work was supported by the National Center for Advancing Translational Sciences (UH3TR000504, UG3TR002158 and UH3TR002178), jointly by the National Center for Advancing Translational Sciences and the Center for the Advancement of Science in Space (UG3TR002178), the National Institute of Environmental Health Sciences (P30ES00703 & T32ES007032) and an unrestricted gift from Northwest Kidney Centers to the Kidney Research Institute. BioServe’s work was supported in part by NASA contracts 80JSC020F0019 and 80JSC017F0129.”

Ra EA, Kim HB, Yun W, Bandaru A, Cho G, Lee S, Anderson MC, Kim MS, Kim H, Oh Y, Lee G.Sex-specific changes in brain organoids from acute simulated galactic cosmic radiation are rescued by targeted ECM pathway stimulation.Adv Funct Mater. 2025 Dec 7;e17942.Journal Impact Factor: 27.7

Funding: “The authors gratefully acknowledge the Translational Research Institute for Space Health (TRISH/NASA) agency for their support (TSRAD 2020 and NNX16AO69A to G.L.) and this work was supported by the Translational Research Institute for Space Health through NASA Cooperative Agreement NNX16AO69A (G.L.).”

Plummer JT, Dezem FS, Cook DP, Park J, Zhang L, Liu Y, Marção M, DuBose H, Wani A, Wise K, Roach M, Harvey K, Wang T, Jensen KB, Morosini N, De Gregorio R, Alonso A, Houlihan SL, Schwartz RE, Hissong E, Snopkowski C, Wrana JL, Ryan N, Butler LM, Church G, Swarbrick A, Mason CE, Martelotto LG.Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets.Nat Biotechnol. 2025 Dec 3.PI: C.E. MasonNote: This article may be obtained online without charge.

Journal Impact Factor: 41.7

Funding: “C.E.M. thanks WorldQuant and GI Research Foundation (GIRF), NASA (80NSSC22K0254, 80NSSC24K0728, 80NSSC24K1052), the National Institutes of Health (P01CA272295, R01CA266279, U54AG089334), the UK Cancer Grand Challenges (SAMBAI), Blood Cancer United (MCL7001-18, LLS 9238-16, 7029-23/22, 7037-25), Boryung and Bumrungrad International Hospital.”

Tyson TL, Perez DF, Otero-Millan J.Distortion of perceived visual space after prolonged horizontal eccentric gaze holding.Vision Res. 2025 Dec 10;240:108729.Note: From the abstract: “Eye movements have long been used as a measure of underlying brain function and pathology. Specifically, rebound nystagmus has provided a behavioral window into the adaptive mechanisms of gaze holding. It is an eye movement aftereffect resulting from maintaining gaze eccentrically for a prolonged duration. Upon returning to central fixation, the eyes drift or “rebound” back toward the previously held gaze location, demonstrating an adaptive process. Little is known about how prolonged eccentric gaze holding, and the accompanying adaptation of the oculomotor system, influences the perception of visual space. Here, we used a variant of the landmark task to assess spatial bias (or lack thereof) with and without prior eccentric gaze holding.”

Journal Impact Factor: 1.4

Funding: “This work was supported by the NASA Ames Research Center Graduate Fellowship Program, the Department of Veterans Affairs (VA) Veteran Readiness and Employment Program, National Institute of Health (NIH) R00EY027846 research project grant, and startup lab funds from the University of California, Berkeley.”

Galli A, Smith H, Blanc M, Foing B, Boithias H, Bolton SJ, Chung S, Coustenis A, Dautriat E, de Vera J-P, Doran P, Dubrulle F, Hesar FF, Frueh C, Garg S, Hedman N, Kim KJ, Lizy-Destrez S, Losch A, Marino A, McKay C, Michel P, Mousis O, Salmeri A, Shah U, R SS, Sims M, Worms J-C, Yano H.Goals and trends in space exploration: An overview of the panel on exploration sessions at the committee on space research general assembly 2024.Life Sci Space Res. 2025 Dec 18. Online ahead of print.Note: This is an Opinion/Position paper.

Journal Impact Factor: 2.8

Funding: H. Smith and C. McKay are affiliated with NASA Ames Research Center.Physical Science papers deriving from NASA support:

Gangopadhyay AK, Beckers M, Schneider S, Sheng Y, Kelton KF.Surface tension and viscosity of Zr₈₀Pt₂₀ measured on the International Space Station and its implication on nucleation mechanism.Metallurgical and Materials Transactions A. 2025 Nov 5.PI: K.F. KeltonNote: ISS results.

Journal Impact Factor: 2.5

Funding: “Work at Washington University was supported by NASA grant 80NSSC21K1649. The authors acknowledge the access to the ISS-EML facility, which is a joint undertaking of the European Space Agency (ESA) and the DLR space administration.”

Thinnakornsutibutr N, Su A, Sharma A, Liao Y-T.Fire scale modeling and effects of buoyant flow on laminar upward flame spread.Appl Energy Combust Sci. 2025 Dec;24:100411.PI: Y-T. LiaoJournal Impact Factor: 6.0

Funding: “This research is supported by NASA Glenn Research Center (Award # 80NSSC22M0011), NASA Science Mission Directorate (Award # 80NSSC24K0310), and NSF (Award # CBET 1942282).”

Thomsen M, Fernandez-Pello C, Urban DL, Olson SL.Extinction of opposed flame spread over thin paper.Proc Combust Inst. 2025;41:105951.PIs: C. Fernandez-Pello, D.L. Urban, S.L. OlsonJournal Impact Factor: 5.2

Funding: “The work presented here was supported by NASA, United States Grants 80NSSC17M0065 and 80NSSC22K0582, and the project Agencia Nacional de Investigación y Desarrollo, ANID Fondecyt Iniciación, Chile 11240482.”

astrobiology, Microgravity, space biology, space medicine, space station, spaceline,

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